Web开馆时间:周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebA series of novel isocombretaquinazolines (isoCoQ) 4 were quickly prepared by coupling N-toluenesulfonylhydrazones with 4-chloroquinazolines under palladium catalysis. These compounds, which can be regarded as isocombretastatin A-4 (isoCA-4) analogues that lack the 3,4,5-trimethoxyphenyl ring, displayed nanomolar-level cytotoxicity against ...
Palladium‐Catalyzed Cross‐Coupling Reaction of Thioglycosides …
WebFeb 1, 2024 · Toward the mavacurane and akuammilane monoterpene indole alkaloids, we developed divergent oxidative couplings between the indole nucleus (at N1 or C7) and the C16-malonate of a common tricyclic model related to strictosidine according to a biosynthetic hypothesis postulated by Hesse and Schmid. These oxidative cyclizations … WebNov 20, 2015 · Leishmania spp., transmitted to humans by the bite of the sandfly vector, are responsible for the three major forms of leishmaniasis, cutaneous, diffuse … how do i call evri
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Web5 Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France. Electronic address: [email protected]. PMID: 33038796 DOI: 10.1016/j.ejmech.2024.112873 Abstract In this work, a series of cyclic bridged analogs of isocombretastatin A-4 (isoCA-4) with phenyl or pyridine linkers were designed and … WebElemental analysis was performed at the “Service de Micro-analyse ICSN” (Gif sur Yvette, France) or “Service d’Analyses–Chromato-Masse BioCIS-UMR 8076” (Châtenay-Malabry, France). High-resolution mass spectra (HRMS) were performed at the MS 3 platform of Sorbonne Université. Thin-layer chromatography was performed on silica gel 60 ... WebWe are currently focusing on the characterization and synthesis of new non-canonical SLs (coll. LBPV University of Nantes, IJPB INRA Versailles, BioCIS Chatenay-Malabry). Given their biological importance, very low bioavailability, complex molecular structures and undefined stereochemistries, these molecules are targets for their total synthesis.. how do i call etsy customer service