Cmaf transcription factor
WebMar 3, 2024 · Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer WebJan 1, 2024 · The MAF transcription factor is a basic region leucine zipper (bZIP)-type that is essential for activation or repression of pro-inflammatory cytokines in T cells, NKT cells, and regulatory T cells ...
Cmaf transcription factor
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WebcMaf is a transcription factor with basic leucine zipper domains that mediate DNA binding to the cMaf recognition element (8,9). cMaf is expressed in monocyte and macrophage lineages, as well as in T cell subsets (10,11). Studies of trans-genic cMaf T helper (Th) cells revealed that cMaf is important WebMar 6, 2007 · Characterization of the α and β cell enriched transcription factors involved in regulating insulin and glucagon expression has revealed not only their significance to islet function, but also to pancreas organogenesis. For example, Pdx1 is necessary for the growth of the endocrine and exocrine compartments, with pancreatic agenesis observed …
WebFeb 23, 2024 · Here, our results show that cMaf, a leucine-zipper transcription factor, is targeted by mTOR in TLR4 signaling, and that cMaf primes TLR4-related inflammatory … WebFeb 23, 2024 · cMaf is a leucine-zipper transcription factor that is involved in cell differentiation, oncogenic transformation, and human diseases; however, the functions of cMaf in inflammatory responses in ...
WebHere, we demonstrate that the transcription factor c-Maf is a critical controller for immunosuppressive macrophage polarization and function in cancer. c-Maf … WebFeb 16, 2012 · We show that the transcription factor c-Maf/c-MAF is crucial for mechanosensory function in mice and humans. The development and function of several …
WebFurthermore, a single-base mutation in genes encoding the large MAF transcription factor group causes congenital renal disease, eye disease, bone disease, diabetes, and tumors in humans. This review describes the functions of large MAF transcription factors in vivo and their relationships with human diseases.
WebMay 25, 2024 · The transcription factor c-Maf was reported to be specifically expressed in primary CD27 − γδT17 and progenitors . We confirmed the expression of c-Maf in … kiwil facility services slWebDec 17, 2013 · The proto-oncogene c-Maf is a transcription factor that plays a critical role in the differentiation of various T helper (T H) cell subsets. The amount of c-Maf … rects detector img 1WebJun 1, 1999 · Two attractive candidates are the Stat6 and GATA-3 transcription factors, both of which are responsive to IL-4 (24, 40, 42, 48, 49). Indeed, ectopic expression of c-Maf in Th1 cells does not permit them to produce IL-4, a finding that is consistent with a role for other transcription factors in driving IL-4 production (Ho et al. 1998). kiwiiz mon compteWebApr 1, 2024 · Here, we demonstrate that the transcription factor c-Maf is a critical controller for immunosuppressive macrophage polarization and function in … rects matlabWebDec 8, 2005 · The virus relies on host transcription factors, such as NFkB and NFAT for its transcription and expression. It has previously been shown that HIV-1 preferentially replicates in Th2 cells, but the mechanism of action for this finding remains unknown. c-maf is a Th2-restricted transcription factor that is critically important for differentiation ... kiwilads commentary tonight at chchWebc-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian ... rects controlWebOct 16, 2011 · Only two transcription factors, c-Maf and AhR, were induced tenfold over their expression in control conditions by the combination of IL-6 and TGF-β. Because AhR is a known positive … kiwiland confectionery