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WebJan 20, 2012 · In particular, GLDC was one of the most highly upregulated genes in multiple analyses of lung TIC-enriched populations, at both the mRNA and protein levels (Figures 2 C and S2 C). GLDC is a key component of the highly conserved glycine cleavage system in amino acid metabolism that catalyzes the breakdown of glycine to form CO 2, ... WebJan 20, 2012 · We found that GLDC induces dramatic changes in glycolysis and glycine/serine metabolism, leading to changes in pyrimidine metabolism to regulate cancer cell proliferation. In the clinic, aberrant activation of GLDC correlates with poorer survival in lung cancer patients, and aberrant GLDC expression is observed in multiple cancer … shoes with the best cushion
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