Ionophore nigericin

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August undefined, 2024

Web6 okt. 2016 · Ionophores such as valinomycin and nigericin are potent tools for studying the impact of ion perturbance on cellular functions. To obtain a broader picture about molecular components involved in mediating the effects of these drugs on yeast cells under respiratory growth conditions, we performed a screening of the haploid deletion mutant … WebIn summary care must be taken when using the putative K+/H+ ionophore nigericin as an experimental tool in synaptosomes, as under standard conditions (i.e. in the presence of high external Na+) nigericin behaves as a Na+/H+ ionophore. Publication types Research Support, Non-U.S. Gov't MeSH terms Animals

Identification of Yeast Mutants Exhibiting Altered Sensitivity to ...

WebNigericin is a carboxylic ionophore that exchanges K + (and to a lesser extent Na +) for H + across cell membranes. If one is successful in choosing [K +] o to match [K +] i, then … WebNigericin acts as a potassium ionophore. It probably activates NLRP3 through its ionophore function which allows the intracellular K+ efflux across the membrane3. Whether the formation of non-selective pannexin-1 pores also contributes to NLRP3 activation upon Nigericin treatment remains unclear4. 1. Mariathasan S. et al., 2006. in a fallacy of relevance

Toxoplasma gondii: induction of egress by the potassium …

Web15 apr. 2016 · The role of carboxylic ionophores (including nigericin and monensin) in lysosomal protein degradation was shown previously, and interestingly monensin inhibited autophagy (29). Thus, monensin and nigericin produced opposite effects on pH and on autophagy and mitophagy that again, suggests the effect of intracellular pH on … Web21 dec. 2004 · The selectivity of nigericin for Pb(2+) exceeds that of ionomycin or monensin and arises, at least in part, from a high stability of nigericin-Pb(2+) complexes. Plots of … WebNigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes.Nigericin can be a NLRP3 activator that induces the release of IL-1β as a NALP3-dependent manner. Nigericin triggers eryptosis, an effect paralleled by ROS formation, and in part due to … ina the voice norway

The Ionophores CCCP and Gramicidin but Not Nigericin Inhibit

Nigericin-induced Na+/H+ and K+/H+ exchange in synaptosomes …

WebNigericin is a carboxylic ionophore that exchanges K + (and to a lesser extent Na +) for H + across cell membranes. If one is successful in choosing [K +] o to match [K +] i, then … WebNigericin inhibits respiration, stimulates glucose consumption, and causes dramatic changes in intracellular concentrations of Na+ and K+ at pHe 7.4 as well as 6.4. The … ina thequeWeb2 dagen geleden · 3.3 IL-6 cytokine secretion in BMDM of diabetic animals stimulated with LPS and Nigericin. We have also investigated the effect of hyperglycemia concomitant with LPS+Nigericin stimulation to assess the secretion of the pro-inflammatory cytokine IL-6 ().After 2, 4, 6 and 24 hours of incubation, BMDM from diabetic and non-diabetic animals … in a fake manner

"WebNigericin acts as an H +, K +, Pb 2+ ionophore. Most commonly it is an antiporter of H + and K +. In the past nigericin was used as an antibiotic active against gram positive bacteria. … " - Ionophore nigericin

Ionophore nigericin

Nigericin is a potent inhibitor of the early stage of vaccinia virus ...

http://www.cnreagent.com/s/sv75647.html Web17 nov. 2024 · However, we found that ionophore nigericin can disturb plasma membrane potential, intracellular pH, mitochondrial membrane potential and autophagy at once. By affecting all of the tested homeostasis-maintaining systems, nigericin induced senolytic action towards stromal and epithelial senescent cells of different origins.

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WebThe term ionophore (from Greek ion carrier or ion bearer) was proposed by Berton Pressman in 1967 when he and his colleagues were investigating the antibiotic … Web1 feb. 1978 · Nigericin, an ionophore that exchanges K+ for H+ across most biologic membranes, reversibly inhibited the proliferative response of human lymphocytes …

Web21 okt. 2024 · Nigericin, another mobile carrier, left both isoforms unaffected. The membrane-integral pore-forming gramicidin evenly inhibited TbAQP2 and TbAQP2 in the … WebNigericin sodium salt acts as a potassium ionophore. It probably activates NLRP3 through the intracellular potassium (K+) efflux across the membrane [1]. Whether the formation of non‑selective pannexin-1 pores also contributes to NLRP3 activation upon … Inflammasome activation with Nano-SiO 2. NLRP3 Inflammasome Inducer - Silicon … Inflammasome activation with Hemozoin crystals. NLRP3 Inflammasome Inducer … Inflammasome activation with Alum. NLRP3 Inflammasome Inducer - Alum … Needle is a component of the type III secretion systems (T3SS) of intracellular … Rod is a component of the type III secretion systems (T3SS) of intracellular bacteria … Purified Flagellin from Pseudomonas aeruginosa.FLA-PA, a ~52 kDa protein, … Inflammasome activation with CPPD crystals. NLRP3 Inflammasome Inducer … Mincle Agonist - Synthetic analog of the cord factor. Trehalose-6,6-dibehenate …

WebAbstract Emerging studies have shown that nigericin, an H +, K + and Pb 2+ ionophore, has exhibited a promising anti-cancer activity in various cancers. However, its anti … Web1 dec. 2013 · The release of IL-1beta in response to nigericin, a potassium ionophore, and maitotoxin, a potent marine toxin, was also found to be dependent on cryopyrin. In contrast to Asc-/- macrophages, cells deficient in the gene encoding cryopyrin (Cias1-/-) activated caspase-1 and secreted normal levels of IL-1beta and IL-18 when infected with Gram …

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WebNigericin sodium salt is a potassium ionophore, exchanges K + for H + across biological membranes, in a similar manner to Valinomycin (Cat. No. 3373). Stimulates mitochondral … ina thanksgivingWebNigericin is a microbial toxin derived from the Gram-positive bacteria Streptomyces hygroscopicus. It induces the release of IL-1β in response to the activation of the NLRP3 … ina theedeWebVaccinia virus is the prototypic member of the Orthopoxvirus genus, which also includes variola and monkeypox virus. In this study, we demonstrate that the carboxylic ionophore nigericin is a potent inhibitor of vaccinia virus replication in several human cell lines. In HeLa cells, we found that the 50% inhibitory concentration of nigericin ... ina theilenWebNigericin, an ionophore that exchanges K+ for H+ across most biologic membranes, reversibly inhibited the proliferative response of human lymphocytes to phytohemagglutinin (PHA). Inhibition occurred at nigericin concentrations of 10 (-8) M or greater, and only during the early event of mitogenesis. ina the voiceWebThe ionophore nigericin equilibrates pH across cells so that the final ion gradients depend on the experimental conditions . Fluorescence intensity was measured in triplicate using the Varioskan LUX Multimode Microplate Reader (Thermo Fisher Scientific) for light emitted at 440 nm and 540 nm with reference excitation wavelengths of 329 nm and 384 nm, … ina theatre you tube in a false color imageWebNigericin effectively causes intracellular parasites to exit their host cell within 30 min of treatment with the drug. Our results show that nigericin-induced egress depends on … in a familiar way