Meg3 gene function
WebThe genes analyzed included the maternally expressed Igf2r, Ube3, and Meg3/Gtl2 (left side of panel), and the paternally expressed Impact and U2af2-rs1 (right side of panel). ( C ) Conserved methylation status of the H19 differentially methylated region in bone marrow cells of recipients with entirely AG- or GG-derived hematopoietic systems. Web24 aug. 2007 · MEG3 is a maternally expressed imprinted gene suggested to function as a non-coding RNA. Our previous studies suggest that MEG3 has a function of tumor …
Meg3 gene function
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WebA maternally expressed gene 3 (MEG3) gene transcripts a 1.6 kb lncRNA whose act as an antitumor component in different cancer cells, such as breast, liver, glioma, colorectal, cervical, gastric, lung, ovarian and osteosarcoma cancer cells. The present review highlights biological function of MEG3 to repress tumor through regulating the Web
Web21 mrt. 2024 · This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in … WebAdditionally, we demonstrate that an evolutionarily conserved intronic region at the MEG3 locus can function as an enhancer in βTC6 β-cells. Using …
Web21 mrt. 2024 · This gene is a member of the non-protein-coding multiple snoRNA host gene family. Two snoRNAs are derived from the introns of this host gene. Although many alternative splice variants have been observed, the gene is thought to have no protein-coding potential. [provided by RefSeq, Jul 2008] GeneCards Summary for SNHG11 Gene Web5 apr. 2024 · MEG3 is well studied in human cancer development. In most cases, it is identified as a tumor suppressor gene though different mechanisms including the induction of p53 protein expression (Li et al., 2015), inhibition of VEGF and Notch signaling pathways (Gordon et al., 2010).
Web2 feb. 2024 · This feature makes MEG3 a key lncRNA that modulates different types of genes. MEG3 can function as a ceRNA in tumors . For example, lncRNA MEG3 is less expressed in prostate cancer, which affects cell proliferation, migration, invasion ability and apoptosis rate by regulating miR-9-5p and QKI-5 .
WebClose Close Submit Cancel Confirm × Modal Title Content robert wilson md npiWeb3 dec. 2014 · The MEG3 isoform was expressed in normal human gonadotrophs, from which clinically nonfunctioning pituitary adenomas are derived. Additional investigation by … robert wilson mirvacWebView unique variants in gene MEG3 View all variants in gene MEG3 Full data view for gene MEG3 Create a new data submission View active genomic custom columns Enable more genomic custom columns View all individuals View all individuals with variants in gene MEG3 Create a new data submission View active custom columns Enable more custom … robert wilson obituary 2023WebProto-oncogenic HCP5 was shown to act as a competing endogenous RNA (ceRNA) to sponge microRNA (miR)‑4656 and then led to the upregulation of miR‑4656 target gene cell migration inducing hyaluronidase 1 (CEMIP), 52 MEG3 functioned as a ceRNA to modulate miR-9-5p/Quaking protein 5 (QKI-5) axis 56 or directly bound to EZH2. 42 However, their … robert wilson msc political research linkedinWeb8 aug. 2015 · Long noncoding RNAs (lncRNAs) have recently emerged as important regulators in governing fundamental biological processes, and many of which are likely to have functional roles in tumorigenesis. Maternally expressed gene 3 (MEG3) gene encodes a lncRNA whose expression is lost in an expanding list of primary human … robert wilson msc political researchWebMaternally Expressed Gene 3 (MEG3) is a long noncoding RNA (lncRNA) that coordinates a diverse array of cellular processes requiring epigenetic regulation of genes and interactions with key signaling proteins and by acting as a competitive endogenous (ce)RNA. Epigenetic modifications driven by in utero nutrition affect MEG3 expression and its role in the … robert wilson hunlock creek paWebAlthough thousands of long noncoding RNAs (lncRNAs) have been identified in porcine growth and development, the regulation mechanisms of functional lncRNAs have not been well explored. In this study, using 5′- and 3′-rapid amplification of cDNA ends (RACE) assays, we obtained two different variants of lncRNA maternally expressed gene 3 … robert wilson lopez island